Differentiation team
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Sébastien Chateauvieux
Institution:
LBMCC
Summary
Published articles Show More
Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450
Published in Cell Death and Disease in Jun 07, 2015
Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na + /K +)-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis ...
Long and Short Non-Coding RNAs as Regulators of Hematopoietic Differentiation
Published in International Journal of Molecular Sciences in Jul 10, 2013
Genomic analyses estimated that the proportion of the genome encoding proteins corresponds to approximately 1.5%, while at least 66% are transcribed, suggesting that many non-coding DNA-regions generate non-coding RNAs (ncRNAs). The relevance of these ncRNAs in biological, physiological as well as in pathological processes increased over the last t...
Heteronemin, a spongean sesterterpene, inhibits TNFα-induced NF-κB activation through proteasome inhibition and induce...
Published in Biochemical Pharmacology
In this study, we investigated the biological effects of heteronemin, a marine sesterterpene isolated from the sponge Hyrtios sp. on chronic myelogenous leukemia cells. To gain further insight into the molecular mechanisms triggered by this compound, we initially performed DNA microarray profiling and determined which genes respond to heteronemin s...