Sandeep Pingle

Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction.

Published in Oncotarget

Metabolic reprogramming is a key feature of tumorigenesis that is controlled by oncogenes. Enhanced utilization of glucose and glutamine are the best-established hallmarks of tumor metabolism. The oncogene c-Myc is one of the major players responsible for this metabolic alteration. However, the molecular mechanisms involved in Myc-induced metabolic...

Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs.

Published in Journal of Translational Medicine

bHLH Transcription factors inhibitors for cancer therapy: general features for in silico drug design.

Published in Current Topics in Medicinal Chemistry

Numerous basic-helix-loop-helix (bHLH) transcription factors (TF) have been found to play important roles in tumor growth and progression. Elucidation of the common features of these TFs can pave the road to possible therapeutic intervention. The existing studies of possible inhibition of these TFs are concentrated on the development of peptides or...