Currently a postdoctoral research fellow at Stanford University School of Medicine, studying Immune aging and T cell metabolism. Previous research experience in cancer therapeutics, nanotechnology and drug delivery.
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Rolando Yanes
Postdoctoral Fellow
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Summary
Published articles Show More
Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug deli...
...Published in Small Group Research
The exocytosis of phosphonate modified mesoporous silica nanoparticles (P-MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P-MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P-MSN exocytosis enhances the drug delivery effect of CPT-...
Development of mesoporous silica nanomaterials as a vehicle for anticancer drug delivery.
Published in Therapeutic Delivery
The development of delivery vehicles that would carry therapeutic agents selectively to cancer cells has become an important focus in biomedical research. Nanoparticles have received much attention because the advances made in this field have resulted in multiple biocompatible materials. In particular, mesoporous silica nanoparticles (MSNs) offer a...
Synthesis of biomolecule-modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells...
Published in Small
Synthetic methodologies integrating hydrophobic drug delivery and biomolecular targeting with mesoporous silica nanoparticles are described. Transferrin and cyclic-RGD peptides are covalently attached to the nanoparticles utilizing different techniques and provide selectivity between primary and metastatic cancer cells. The increase in cellular upt...
Experience
Postdoctoral Fellow Since July 2013
Stanford University (Palo Alto US)
Postdoctoral fellow studying Immune aging and T cell metabolism.
Education
PhD September 2007 - June 2013
UCLA (Los Angeles US)
Studied the use of Mesoporous Silica Nanoparticles as drug delivery vehicles and their exocytosis from cells.
