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Published in Frontiers in Neuroscience
In this paper, we propose an approach for template-based shape analysis of large datasets, using diffeomorphic centroids as atlas shapes. Diffeomorphic centroid methods fit in the Large Deformation Diffeomorphic Metric Mapping (LDDMM) framework and use kernel metrics on currents to quantify surface dissimilarities. The statistical analysis is based...
Published in Journal of Antimicrobial Chemotherapy
Published in Molecular Autism
Background The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments wi...
Motivated by applications in neuroanatomy, we propose a novel methodology for estimating the heritability which corresponds to the proportion of phenotypic variance which can be explained by genetic factors. Estimating this quantity for neuroanatomical features is a fundamental challenge in psychiatric disease research. Since the phenotypic variati...
Published in uman Brain Mapping - 2015, Honolulu, United States
Incomplete hippocampal inversion (IHI) is an atypical anatomical pattern of the hippocampus. It has been mostly described in patients with epilepsy, in particular with malformations of cortical development but also in temporal lobe epilepsy (Baulac et al. 1998; Bernasconi et al. 2005; Bajic et al. 2009), with a prevalence of 30%-50%. However, IHI a...
Published in 20th Annual Meeting of the Organization for Human Brain Mapping (OHBM)
Magnetic resonance imaging at 7 T and beyond, enables imaging the full cortex at isotropic resolutions below 0.5 mm. Allowing the study of intra-cortical features such as cortical layers. In order to describe and analyse these features, the cortex needs to be described in ways that respect its structure across its whole thickness. A method is propo...
Applied and theoretical neuroanatomy; UMR 7502 (Institut Pasteur) Génétique Humaine et Fonctions Cognitives; UFR Sciences du Vivant