Renwei Chen
Post Doc Associate
Institution:
Ruoslahti Lab
Santa Barbara, CA, United States
https://www.mysciencework.com/profile/renwei.chen
Summary
Published articles Show More
Application of a proapoptotic peptide to intratumorally spreading cancer therapy.
Published in Cancer Research
Bit1 is a proapoptotic mitochondrial protein associated with anoikis. Upon cell detachment, Bit1 is released into the cytoplasm and triggers caspase-independent cell death. Bit1 consists of 179 amino acids; for the C-terminal, two thirds of the molecule functions as a peptidyl-tRNA hydrolase, whereas the N-terminus contains a mitochondrial localiza...
Protein kinase D is a positive regulator of Bit1 apoptotic function.
Published in Journal of Biological Chemistry
Bit1 (Bcl-2 inhibitor of transcription) is a mitochondrial protein that induces caspase-independent apoptosis upon its release into the cytoplasm. Bit1 is primarily associated with anoikis (cell death induced by detachment from the extracellular matrix), because the apoptotic function of Bit1 is inhibited by integrin-mediated cell attachment but no...
TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells.
Published in Molecular Cancer Research
TLE1 is a Groucho-related transcriptional repressor protein that exerts survival and antiapoptotic function in several cellular systems and has been implicated in the pathogenesis of cancer. In the present study, we found that TLE1 is a regulator of anoikis in normal mammary epithelial and breast carcinoma cells. The induction of apoptosis followin...
Contact me
(805) 893-5378
