In silico characterization of the interaction between LSKL peptide, a LAP-TGF-beta derived peptide, and ADAMTS1
Metalloproteases involved in extracellular matrix remodeling play a pivotal role in cell response by regulating the bioavailability of cytokines and growth factors. Recently, the disintegrin and metalloprotease, ADAMTS1 has been demonstrated to be able to activate the transforming growth factor TGF-β, a major factor in fibrosis and cancer. The KTFR...
Supplementary data are available at Bioinformatics online.
Published in Neuromuscular Disorders
Peptide structure identification is an important contribution to the further characterization of the residues involved in functional interactions. De novo structure peptide prediction has, in the past few years, made significant progresses that make reasonable, for peptides up to 50 amino acids, its use for the fast identification of their structur...
Responsable de l'équipe Since 2014
Structure-based peptide design; Molécules Thérapeuthiques in Silico; UFR Sciences du Vivant