Pierre-Antoine Defossez

MyoD reprogramming requires Six1 and Six4 homeoproteins: genome-wide cis-regulatory module analysis

Myogenic regulatory factors of the MyoD family have the ability to reprogram differentiated cells toward a myogenic fate. In this study, we demonstrate that Six1 or Six4 are required for the reprogramming by MyoD of mouse embryonic fibroblasts (MEFs). Using microarray experiments, we found 761 genes under the control of both Six and MyoD. Using Myo...

MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domain.

Published in The American Journal of Cardiology

MBD5 and MBD6 are two members of the methyl-CpG-binding domain (MBD) family of proteins that are poorly characterized. Studies performed thus far have failed to show binding of the MBD5 and MBD6 MBD to methylated DNA. Here, we show that both MBD5 and MBD6 interact with the mammalian PR-DUB Polycomb protein complex in a mutually exclusive manner. St...

The RBBP6/ZBTB38/MCM10 Axis Regulates DNA Replication and Common Fragile Site Stability

Faithful DNA replication is essential for the maintenance of genome integrity. Incomplete genome repli-cation leads to DNA breaks and chromosomal rearrangements , which are causal factors in cancer and other human diseases. Despite their importance, the molecular mechanisms that control human genome stability are incompletely understood. Here, we r...

Biological Functions of Methyl-CpG-Binding Proteins

Published in Presse médicale (Paris, France : 1983)