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Mo Movassaghi
Co-Leader of the Late-Stage C-H Functionalization Theme, Massachusetts Institute of Technology
Institution:
CCHF
Summary
Published articles Show More
Concise Total Synthesis of (+)-Luteoalbusins A and B
Published in Organic and Medicinal Chemistry Letters
The first total synthesis of (+)-luteoalbusins A and B is described. Highly regio- and diastereoselective chemical transformations in our syntheses include a Friedel-Crafts C3-indole addition to a cyclotryptophan-derived diketopiperazine, a late-stage diketopiperazine dihydroxylation, and a C11-sulfidation sequence, in addition to congener-specific...
Pd(II)-Catalyzed meta-C–H Olefination, Arylation, and Acetoxylation of Indolines Using a U-Shaped Template
Published in Journal of the American Chemical Society
meta-C-H olefination, arylation, and acetoxylation of indolines have been developed using nitrile-containing templates. The combination of a monoprotected amino acid ligand and the nitrile template attached at the indolinyl nitrogen via a sulfonamide linkage is crucial for the meta-selective C-H functionalization of electron-rich indolines that are...
C7-Derivatization of C3-Alkylindoles Including Tryptophans and Tryptamines
Published in The Journal of Organic Chemistry
A versatile strategy for C7-selective boronation of tryptophans, tryptamines, and 3-alkylindoles by way of a single-pot C2/C7-diboronation–C2-protodeboronation sequence is described. The combination of a mild iridium-catalyzed C2/C7-diboronation followed by an in situ palladium-catalyzed C2-protodeboronation allows efficient entry to valuable C7-bo...
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