Head of Cancer Epigenetics team;
Main research activities:
I. Investigation of epigenetic mechanisms involved in tumorigenesis
II. Identification and characterization of new epigenetic modulators
III. Investigation of mechanisms by which epigenetic modulators induce anti-tumor activities for preventive and therapeutic purposes
Published in Pharmacological Research
Despite the discovery of tyrosine kinase inhibitors (TKIs) for the treatment of breakpoint cluster region-Abelson (BCR-ABL) + cancer types, patients with chronic myeloid leukemia (CML) treated with TKIs develop resistance and severe adverse effects. Combination treatment, especially with a histone deacetylase (HDAC) 6 inhibitor (HDAC6i), appears to...
Published in Clinical Epigenetics
Background: Chronic myeloid leukemia (CML) pathogenesis is mainly driven by the oncogenic breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) fusion protein. Since BCR-ABL displays abnormal constitutive tyrosine kinase activity, therapies using tyrosine kinase inhibitors (TKis) such as imatinib represent a major bre...
Published in Journal of Medicinal Chemistry
A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting sirtuins in glioma cells. Based on computational docking combined to in vitro sirtuin 1/2 inhibition assays, we selected compound 18 [R/S-N-3-cyano...
Role, mechanisms and therapeutic potential of epigenetics in cancer
Department of Environmental Health
Recipient of a grant from the Luxembourgish government
Laboratoire de Spectroscopie Biomoléculaire; Unité MéDian, CNRS FRE 2141, IFR 53, Faculty of Pharmacy
Laboratory of parasitology
PhD thesis in molecular and cellular biology
Biochemistry; 1st year: Faculty of Sciences, 2nd year: Faculty of Pharmacy
Life sciences-Biochemistry; Faculty of Sciences
Post-doctoral scholars research forum (Cincinnati, Ohio, USA)
From the Ministry for Higher Education and Research in Luxembourg (2001-2004)
