Head of Cancer Epigenetics team;
Main research activities:
I. Investigation of epigenetic mechanisms involved in tumorigenesis
II. Identification and characterization of new epigenetic modulators
III. Investigation of mechanisms by which epigenetic modulators induce anti-tumor activities for preventive and therapeutic purposes
...
Published in Biochemical Pharmacology in Jan 02, 2016
Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including a-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing ...
Published in Anti-Cancer Agents in Medicinal Chemistry in Jan 11, 2015
Despite recent advances in the treatment of chronic myelogenous leukemia (CML), the development of drug resistance and minimal residual disease remain major challenges for the treatment of CML patients, thus highlighting the need to develop innovative new approaches to improve therapeutic outcome. Myrtucommulone A (MCA) is a nonprenylated acylphlor...
Published in Biotechnology Advances
Carcinogenesis is a complex and multistep process that involves the accumulation of successive transformational events driven by genetic mutations and epigenetic alterations that affect major cellular processes and pathways such as proliferation, differentiation, invasion and survival. Massive deregulation of all components of the epigenetic machin...
Role, mechanisms and therapeutic potential of epigenetics in cancer
Department of Environmental Health
Recipient of a grant from the Luxembourgish government
Laboratoire de Spectroscopie Biomoléculaire; Unité MéDian, CNRS FRE 2141, IFR 53, Faculty of Pharmacy
Laboratory of parasitology
PhD thesis in molecular and cellular biology
Biochemistry; 1st year: Faculty of Sciences, 2nd year: Faculty of Pharmacy
Life sciences-Biochemistry; Faculty of Sciences
Post-doctoral scholars research forum (Cincinnati, Ohio, USA)
From the Ministry for Higher Education and Research in Luxembourg (2001-2004)
0000-0003-0550-9538
