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Anesthetic Drug-Induced Neurotoxicity and Compromised Neural Stem Cell Proliferation
Published in Journal of Drug and Alcohol Research
Introduction. Because of obvious concerns, it is not possible to thoroughly explore the adverse effects of anesthetics in children. However, the availability of neural stem cell derived models has provided an invaluable tool to examine the etiology of neurotoxicity associated with developmental exposure to general anesthetics. Stem cells and neurot...
The Evaluation of Sevoflurane-Induced Apoptotic Neurodegeneration with MicroPET Using [18F]-DFNSH in the Developing Rat ...
...Published in Journal of Drug and Alcohol Research
General anesthetic-induced apoptotic neurodegeneration confirmed in animal models caused substantial concerns over the safety of pediatric patients undergoing general anesthesia. Therefore, studies in search of translational molecular probes for labeling apoptotic neurons are imperative. The purpose of the current study is to examine the utility of...
Assessment of Potential Neuronal Toxicity of Inhaled Anesthetics in the Developing Nonhuman Primate
Published in Journal of Drug and Alcohol Research
Anesthetics have been used for years in pediatric patients without clinical evidence of adverse central nervous system (CNS) sequelae. In the current study, postnatal day (PND) 5–6 rhesus monkeys were exposed to nitrous oxide (N 2 O; 70%) alone, isoflurane (ISO; 1.0%) alone, or N 2 O plus ISO for 8 h. Six hours after completion of anesthetic admini...
