Matteo obtained his MSc. in Bioinformatics at the Technical University of Denmark in 2006 and in Biomedical Engineering at Politecnico di Milano in 2008. He graduated with his PhD. in Molecular Medicine from the European Institute of Oncology, working with Dr. Francesca Ciccarelli. There, he worked on the evolution of protein interaction networks through gene duplication and on the identification of new cancer genes. Matteo joined the Frazer lab in April 2013, where he has been working on the identification of driver mutation outside coding regions in breast cancer.
Matteo D'Antonio
Postdoctoral Researcher
Institution:
Frazer Lab
La Jolla, CA, United States
https://www.mysciencework.com/profile/matteo.d.antonio
Summary
Published articles Show More
Biased estimates of clonal evolution and subclonal heterogeneity can arise from PCR duplicates in deep sequencing experi...
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Published in Genome Biology
Accurate allele frequencies are important for measuring subclonal heterogeneity and clonal evolution. Deep-targeted sequencing data can contain PCR duplicates, inflating perceived read depth. Here we adapted the Illumina TruSeq Custom Amplicon kit to include single molecule tagging (SMT) and show that SMT-identified duplicates arise from PCR. We de...
