Mary Saunders
Institution:
Kit Lam Lab
Sacramento, CA, United States
https://www.mysciencework.com/profile/mary.saunders
Summary
Published articles Show More
Rapid discovery of death ligands with one-bead-two-compound combinatorial library methods.
Published in ACS Combinatorial Science
The one-bead-one-compound (OBOC) technology enables one to generate thousands to millions of chemical molecules on resin beads (90 μm diameter) such that each bead displays 10(13) copies of the same chemical entity. Whole-cell binding assays have been developed to screen OBOC combinatorial libraries for ligands that bind to specific cell surface re...
Reversing bone loss by directing mesenchymal stem cells to bone.
...Published in The International Journal Of Cell Cloning
Bone regeneration by systemic transplantation of mesenchymal stem cells (MSCs) is problematic due to the inability to control the MSCs commitment, growth, and differentiation into functional osteoblasts on the bone surface. Our research group has developed a method to direct the MSCs to the bone surface by conjugating a synthetic peptidomimetic li...
Differentiation of cancer cell origin and molecular subtype by plasma membrane N-glycan profiling.
...Published in Journal of Proteome Research
In clinical settings, biopsies are routinely used to determine cancer type and grade based on tumor cell morphology, as determined via histochemical or immunohistochemical staining. Unfortunately, in a significant number of cases, traditional biopsy results are either inconclusive or do not provide full subtype differentiation, possibly leading to ...
