Martine Cohen-Solal

Dementia is a major risk factor for hip fractures in patients with chronic kidney disease

Published in Osteoporosis International

Chronic kidney disease increases the risk of hip fractures which can be promoted by dementia. We here showed that dementia increased the risk of hip fractures in dialysis patients, but in a similar manner than without dialysis. Attention should be paid to dementia to prevent hip fractures. Introduction: Hip fractures (HF) are associated with sig...

Reimbursment of the serum CTX assay in France: the clinical biology nomenclature is incoherent

Published in Annales de biologie clinique

Le comité scientifique du Groupe de recherche et d’information sur les ostéoporoses (GRIO), a été récemment informé de cas de non-remboursement du dosage du CTX sérique. Cette situation qui pose problème à la bonne prise en charge des patients vient d’une incohérence dans la nomenclature des analyses de biologie médicale (NABM).La concentration sér...

SRC Kinase Inhibition with Saracatinib Limits the Development of Osteolytic Bone Disease in Multiple Myeloma

Published in Oncotarget

Multiple myeloma (MM)-associated osteolytic bone disease is a major cause of morbidity and mortality in MM patients and the development of new therapeutic strategies is of great interest. The proto-oncogene SRC is an attractive target for such a strategy. In the current study, we investigated the effect of treatment with the SRC inhibitor saracatin...

Mechanisms of Calcium Pyrophosphate Crystal-induced Inflammation

Published in 50th Annual Scientific Meeting of the European Society for Clinical Investigation Paris

Hydrated calcium pyrophosphate (CPP) crystal deposition occurs in hyaline and fibrocartilage. Monoclinic and triclinic dihydrated phases, m-CPPD and t-CPPD respectively, are the two phases of CPP crystals identified in human joints and synovial fluids. They are associated with different clinical manifestations including asymptomatic, self-resolving...

Galectin-1 attenuates bone resorption by osteoclasts

Published in EMBO Workshop: Transducing glycan information into function: Lessons from galectins

Peer reviewed

Lectin-glycoprotein interactions in the diagnosis and biology of myeloma-related bone disease

Published in 2nd Herbert Fleisch Workshop of the International Bone and Mineral Society

Peer reviewed

Rôle de la furine dans la régulation de la matrice cartilagineuse (applications aux pathologies articulaires)

La furine est une proprotéine convertase responsable de la maturation de nombreux substrats dont les métalloprotéases matricielles du cartilage. Afin de déterminer le rôle de la furine dans deux pathologies affectant les articulations, la polyarthrite rhumatoïde et l'arthrose, nous avons réalisé des études sur deux modèles de souris mimant ces path...

Implication de l'os sous-chondral dans la pathogénie de l'arthrose (interaction os-cartilage)

FR

Régulation par le 17β estradiol sur la différenciation, l' activité et l' apoptose des ostéoclastes humains et murins

FR