Martin Bartas currently works at the Department of Biology and Ecology, University of Ostrava. Martin does research in Molecular Biology, Cancer Research and Bioinformatics. Their most recent publication is 'Bioinformatics analyses and in vitro evidence for five and six stacked G-quadruplex forming sequences'.
Published in Molecules
The role of local DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, the significance of G-quadruplexes was demonstrated in the last decade, and their presence and functional relevance has been demonstrated in many genomes, including humans. In this study, we analyzed t...
Published in Molecules
The importance of local DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, G-quadruplexes are perhaps the most well-characterized to date, and their presence has been demonstrated in many genomes, including that of humans. G-quadruplexes are selectively bound by many re...
Published in Biochimie
Quadruplexes are noncanonical DNA structures that arise in guanine rich loci and have important biological functions. Classically, quadruplexes contain four stacked intramolecular G-tetrads. Surprisingly, although some algorithms allow searching for longer than 4G tracts for quadruplex formation, these have not yet been systematically studied. Ther...
Recently we have for the first time described more than four-stacked intramolecular G-quadruplex forming sequences. These sequences are very rare in human genome, but interestingly span important locations such promoters or sites of chromatin acetylation in most cases. Also preferential binding of tumor suppressor protein p53 to quadruplex DNA st...
Aim of our work was to study preferential binding of BRCA1 and p53 proteins to different forms of G-quadruplexes found in promotor regions of p21 and ESR1 genes. Based on enhanced occurrence of sequences, that are able to form G-quadruplexes in promotor regions of large scale of genes including genes that are involved in cell cycle regulation, ou...
