The Zúñiga lab is interested in the regulation of immune responses in health and disease. Major Histocompatibility Complex (MHC) molecules (called HLA molecules in humans) present self, tumor, and pathogen-derived antigens to the T cells. The presentation of MHC molecules in different cellular contexts is of paramount importance in determining immune responsiveness versus tolerance. One major project in the lab focuses on mechanisms of immunological tolerance to cutaneous antigens. We have found that skin-derived regulatory T cells can induce .....
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