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Published in American Journal of Respiratory Cell and Molecular Biology
Constitutive activation of the mammalian target of rapamycin (mTOR) complexes mTORC1 and mTORC2 is associated with pulmonary hypertension (PH) and sustained growth of pulmonary artery (PA) smooth muscle cells (SMCs). We investigated whether selective mTORC1 activation in SMCs induced by deleting the negative mTORC1 regulator tuberous sclerosis comp...
Published in Cell Reports
Loss of skeletal muscle mass and force aggravates age-related sarcopenia and numerous pathologies, such as cancer and diabetes. The AKT-mTORC1 pathway plays a major role in stimulating adult muscle growth; however, the functional role of its downstream mediators in vivo is unknown. Here, we show that simultaneous inhibition of mTOR signaling to bot...
Nous étudions la fonction de mTOR dans la prolifération physiologique, régénératrice et tumorale en utilisant plusieurs approches qui vont de la mutagenèse dirigée chez la souris aux traitements pharmacologiques. Nous avons pu mettre en évidence une surprenante spécificité fonctionnelle des substrats de mTOR, Akt et S6K, qui interviennent dans des ...
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Contrôle de la croissance cellulaire par les nutriments; Biologie cellulaire (Croissance et Signalisation); INSERM U1151 - CNRS UMR 8253, Institut Necker-Enfants Malades; Faculté de Médecine