
Marianne Chigbrow
Laboratory Manager; Staff Research Associate
Summary
Published articles Show More
Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodyni...
...Published in Brain Behavior and Immunity
Objective: Pain resulting from local tissue injury or inflammation typically resolves with time. Frequently, however, this pain may unexpectedly persist, becoming a pathological chronic state. Increasingly, the innate and adaptive immune systems are being implicated in the initiation and maintenance of these persistent conditions. In particular, To...
Acute wounding alters the beta2-adrenergic signaling and catecholamine synthetic pathways in keratinocytes.
...Published in Journal of Investigative Dermatology
Keratinocyte migration is critical for wound re-epithelialization. Previous studies showed that epinephrine activates the beta2-adrenergic receptor (B2AR), impairing keratinocyte migration. Here, we investigated the keratinocyte catecholamine synthetic pathway in response to acute trauma. Cultured keratinocytes were scratch wounded and expression l...