Dedication to the study of the cell and the molecular biology of cancer.
Professor of Biochemistry at the Seoul National University (SNU).
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Marc Diederich
Professor
Institution:
LBMCC
Seoul, South Korea
https://www.mysciencework.com/profile/marc.diederich
Summary
Published articles Show More
The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptos...
...Published in Pharmacological Research
Despite the discovery of tyrosine kinase inhibitors (TKIs) for the treatment of breakpoint cluster region-Abelson (BCR-ABL) + cancer types, patients with chronic myeloid leukemia (CML) treated with TKIs develop resistance and severe adverse effects. Combination treatment, especially with a histone deacetylase (HDAC) 6 inhibitor (HDAC6i), appears to...
Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/M...
...
Published in Clinical Epigenetics
Background: Chronic myeloid leukemia (CML) pathogenesis is mainly driven by the oncogenic breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL) fusion protein. Since BCR-ABL displays abnormal constitutive tyrosine kinase activity, therapies using tyrosine kinase inhibitors (TKis) such as imatinib represent a major bre...
Inflammation regulates long non-coding RNA-PTTG1-1:1 in myeloid leukemia.
...Published in Haematologica
No abstract available
Conferences Show More
9th International International society for the study of xenobiotics Meeting
Prostate cancer is the most commun cancer in men in the western world. Lifestyle, diet and environmental as well as genetic factors (e.g. disregulations of the Wingless (Wnt) signaling pathway) promote the malignant transformation of healthy prostatic epithelium. Due to the high prevalence and the slow progressive development of prostate cancer, pr...
Books Show More
Oxidative Stress and Apoptosis
Published in Redox Signaling and Regulation in Biology and Medicine
The decision of a cell to die is triggered by the imbalance between the positive signals, those needed for continuing to survive (i.e. growth factors), and negative signals (i.e. DNA damages, increased levels of oxidants) [1]. There are two major mechanisms of cell death: necrosis and apoptosis. The severity of the injury leads the cells to decide ...
Preprints Show More
Roles of Apoptosis and Cellular Senescence in Cancer and Aging
Published in Current Topics in Medicinal Chemistry
Cancer and aging are two similar processes representing the final outcome of time-dependent accumulation of various irreversible dysfunctions, mainly caused by stress-induced DNA and cellular damages. Apoptosis and senescence are two types of cellular response to damage that are altered in both cancer and aging, albeit through different mechanisms....
Experience
Professor Since September 2012
Seoul National University (Seoul KR)
Professor of Biochemistry and principal investigator conducting independent research, leading and training a 10-person group including PhD scientists and PhD and MSc candidates.
