Dedication to the study of the cell and the molecular biology of cancer.
Professor of Biochemistry at the Seoul National University (SNU).
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Marc Diederich
Professor
Institution:
LBMCC
Seoul, South Korea
https://www.mysciencework.com/profile/marc.diederich
Summary
Published articles Show More
Discovery and Characterization of R/S-N-3-Cyanophenyl-N'- (6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H- 1-ben...
...Published in Journal of Medicinal Chemistry in May 08, 2017
A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting sirtuins in glioma cells. Based on computational docking combined to in vitro sirtuin 1/2 inhibition assays, we selected compound 18 [R/S-N-3-cyano...
Non-canonical programmed cell death mechanisms triggered by natural compounds
Published in Seminars in Cancer Biology in May 31, 2016
4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90a chaperone ac...
Published in Biochemical Pharmacology in Jan 02, 2016
Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including a-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing ...
Conferences Show More
9th International International society for the study of xenobiotics Meeting
Prostate cancer is the most commun cancer in men in the western world. Lifestyle, diet and environmental as well as genetic factors (e.g. disregulations of the Wingless (Wnt) signaling pathway) promote the malignant transformation of healthy prostatic epithelium. Due to the high prevalence and the slow progressive development of prostate cancer, pr...
Preprints Show More
Roles of Apoptosis and Cellular Senescence in Cancer and Aging
Published in Current Drug Targets in Feb 16, 2016
Cancer and aging are two similar processes representing the final outcome of time-dependent accumulation of various irreversible dysfunctions, mainly caused by stress-induced DNA and cellular damages. Apoptosis and senescence are two types of cellular response to damage that are altered in both cancer and aging, albeit through different mechanisms....
Experience
Professor Since September 2012
Seoul National University (Seoul KR)
Professor of Biochemistry and principal investigator conducting independent research, leading and training a 10-person group including PhD scientists and PhD and MSc candidates.
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0000-0003-0115-4725