Lise Roth
Post Doc Associate
Institution:
Ruoslahti Lab
Santa Barbara, CA, United States
https://www.mysciencework.com/profile/lise.roth
Summary
Published articles Show More
Transtumoral targeting enabled by a novel neuropilin-binding peptide
Published in Oncogene
We have recently described a class of peptides that improve drug delivery by increasing penetration of drugs into solid tumors. These peptides contain a C-terminal C-end Rule (CendR) sequence motif (R/K)XX(R/K), which is responsible for cell internalization and tissue-penetration activity. Tumor-specific CendR peptides contain both a tumor-homing m...
De novo design of a tumor-penetrating peptide.
...Published in Cancer Research
Poor penetration of antitumor drugs into the extravascular tumor tissue is often a major factor limiting the efficacy of cancer treatments. Our group has recently described a strategy to enhance tumor penetration of chemotherapeutic drugs through use of iRGD peptide (CRGDK/RGPDC). This peptide comprises two sequence motifs: RGD, which binds to αvβ3...
Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient m...
...Published in Proceedings of the National Academy of Sciences
The ability to selectively deliver compounds into atherosclerotic plaques would greatly benefit the detection and treatment of atherosclerotic disease. We describe such a delivery system based on a 9-amino acid cyclic peptide, LyP-1. LyP-1 was originally identified as a tumor-homing peptide that specifically recognizes tumor cells, tumor lymphatics...
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