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The mammary gland is remarkable in its capacity to self renew since every pregnancy results in prodigious cell growth to prepare for milk production. Stem cells required to maintain this process reside in specialized environments (niches) squeezed between the luminal and myoepithelial cells layers. We are exploring how loss of Slits and Netrins disrupt these niches, and the biological consequences of this disruption.

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Dept. Mcd Biology Stem Cells And Self Renewal

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