Dr. Frazer is a professor and the founding chief of the Division of Genome Information Sciences in the Department of Pediatrics, Director of UC San Diego’s Institute for Genomic Medicine and a leader at the university’s Clinical and Translational Research Institute. Prior to joining UCSD in 2009, Dr. Frazer was Professor of Translational Genomics at the Scripps Research Institute and, previously, Vice President of Genomic Biology at Perlegen Sciences. Dr. Frazer has spent the past 25 years studying various aspects of functional and structural human genomics, and her contributions include pioneering cross-species DNA sequence comparisons between humans and mice, generating the content now publicly available in the “HapMap Phase II,” and developing novel methods for identifying and functionally annotating variants underlying GWAS signals. Dr. Frazer’s current research studies are supported by the National Institutes of Health, the K.G. Jebsen Medical Foundation, the California Institute for Regenerative Medicine as well as industry and cross-institutional collaborations.
Published in Annual Review of Genomics and Human Genetics
Published in Proceedings of the National Academy of Sciences
Formative research suggests that a human embryonic stem cell-specific alternative splicing gene regulatory network, which is repressed by Muscleblind-like (MBNL) RNA binding proteins, is involved in cell reprogramming. In this study, RNA sequencing, splice isoform-specific quantitative RT-PCR, lentiviral transduction, and in vivo humanized mouse mo...
Network-based analysis identifies epigenetic biomarkers of esophageal squamous cell carcinoma progression.
Published in Bioinformatics