Kazuki Sugahara
Post Doc Associate
Institution:
Ruoslahti Lab
Santa Barbara, CA, United States
https://www.mysciencework.com/profile/kazuki.sugahara
Summary
Published articles Show More
Transtumoral targeting enabled by a novel neuropilin-binding peptide
Published in Oncogene
We have recently described a class of peptides that improve drug delivery by increasing penetration of drugs into solid tumors. These peptides contain a C-terminal C-end Rule (CendR) sequence motif (R/K)XX(R/K), which is responsible for cell internalization and tissue-penetration activity. Tumor-specific CendR peptides contain both a tumor-homing m...
Selection of phage-displayed peptides on live adherent cells in microfluidic channels.
...Published in Proceedings of the National Academy of Sciences
Affinity reagents that bind to specific molecular targets are an essential tool for both diagnostics and targeted therapeutics. There is a particular need for advanced technologies for the generation of reagents that specifically target cell-surface markers, because transmembrane proteins are notoriously difficult to express in recombinant form. We...
Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs.
Published in Science
Poor penetration of anticancer drugs into tumors can be an important factor limiting their efficacy. We studied mouse tumor models to show that a previously characterized tumor-penetrating peptide, iRGD, increased vascular and tissue permeability in a tumor-specific and neuropilin-1-dependent manner, allowing coadministered drugs to penetrate into ...
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