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Justin Du Bois
Catalyst Design Theme Leader, Stanford University
Institution:
CCHF
Summary
Published articles Show More
An expedient synthesis of maraviroc (UK-427,857) via C–H functionalization
Published in Tetrahedron Letters
A new, concise synthesis of the CCR-5 receptor antagonist maraviroc (UK-427,857) from 3-phenyl-1-propanol has been completed in four steps featuring a site-selective C–H functionalization.
Non-directed allylic C–H acetoxylation in the presence of Lewis basic heterocycles
Published in Advances in Chemical Engineering and Science
We outline a strategy to enable non-directed Pd(II)-catalyzed C-H functionalization in the presence of Lewis basic heterocycles. In a high-throughput screen of two Pd-catalyzed C-H acetoxylation reactions, addition of a variety of N-containing heterocycles is found to cause low product conversion. A pyridine-containing test substrate is selected as...
Analyzing Site Selectivity in Rh2(esp)2-Catalyzed Intermolecular C–H Amination Reactions
Published in Journal of the American Chemical Society
Predicting site selectivity in C-H bond oxidation reactions involving heteroatom transfer is challenged by the small energetic differences between disparate bond types and the subtle interplay of steric and electronic effects that influence reactivity. Herein, the factors governing selective Rh2(esp)2-catalyzed C-H amination of isoamylbenzene deriv...
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Metal-Catalyzed Oxidations of C–H to C–N Bonds
Published in Topics in Current Chemitry
This chapter offers a general review of selective methods for the oxidative conversion of C–H to C–N bonds. Special focus has been given to the many disparate catalyst types that are capable of promoting this unique transformation.
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