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Jinfeng Shen
Participant-Stanford Ignite Program
Institution:
AIMS
Summary
Published articles Show More
APR-246/PRIMA-1MET rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 m...
...Published in Proceedings of the National Academy of Sciences
p53 and p63 share extensive sequence and structure homology. p53 is frequently mutated in cancer, whereas mutations in p63 cause developmental disorders manifested in ectodermal dysplasia, limb defects, and orofacial clefting. We have established primary adult skin keratinocytes from ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) sy...
PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2
Published in Oncogene
p53 mutations occur frequently in human tumors. The low-molecular-weight compound PRIMA-1 MET reactivates mutant p53, induces apoptosis in human tumor cells and inhibits tumor xenograft growth in vivo. Here, we show that PRIMA-1 MET induces mutant p53-dependent mito-chondria-mediated apoptosis through activation of caspase-2 with subsequent cytochr...
Experience
Participant-Stanford Ignite Program January 2014 - March 2014
Stanford Graduate School of Business (Palo Alto US)
Certification program for entrepreneurs and people interested in innovation. Program includes 100- hour class sessions by GSB faculty and 150-hour team project to develop business model and pitch to VCs, for an E commerce venture building an online market place for life science products. Skills learned include: - Core business skills: marketing, operations, strategy, finance and economics - Applied skills: negotiation, teamwork, public speaking, leadership and pitching - Product design and prototyping
iFarm program participant September 2013 - January 2014
Stanford Office of Technology Licensing (Palo Alto US)
Conducted due diligence on technologies patented by Stanford inventors in the OTL Tech Finder database with an interdisciplinary team of Stanford affiliates.
Postdoctoral fellow Since April 2011
Stanford University (Palo Alto US)
Investigate the functional requirement of the LSC (Leukemia Stem Cell) prognostic genes and the relevant molecular pathways by using human AML cell lines / primary human AML in vitro culture and in vivo mice model.
Education
Ph.D. in Molecular Biology & Cancer Biology June 2004 - December 2010
Karolinska Institutet (Stockholm SE)
Investigated the mechanism of mutant p53 reactivation in cancer by small molecule compounds PRIMA-1 and STIMA.
Karolinska institutet Master's degree in Stockholm Graduate School September 2003 - June 2004
Karolinska Institutet (Stockholm SE)
Molecular Biology
Bachelor's degree September 1999 - June 2003
Shanghai Normal University (Shanghai CN)
Life and Environmental Science
Awards
The Swedish Research Council postdoctoral fellowship April 2011
Postdoctoral Scholar at Stanford School of Medicine
Stockholm Graduate School Fellowship September 2003
Master student at Stockholm Graduate School
