Jason DeHart

Viruses are obligate intracellular pathogens typically with minimal genomes and limited coding capacity. As such, viruses have evolved to encode a minimal number of highly potent genes capable of disrupting large complex cellular signaling networks in order to commandeer the host cellular machinery. Since joining the O'Shea lab, I have been using DNA viruses to interrogate critical pathways targeted by both viruses and cancer in order to elucidate potentially key druggable targets.