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Published in Nature Communications
Artificial metalloenzymes (ArMs) formed by incorporating synthetic metal catalysts into protein scaffolds have the potential to impart to chemical reactions selectivity that would be difficult to achieve using metal catalysts alone. In this work, we covalently link an alkyne-substituted dirhodium catalyst to a prolyl oligopeptidase containing a gen...
Published in Chem-Bio Informatics Journal
As good as the real thing: Strain‐promoted azide–alkyne cycloaddition can be used to generate artificial metalloenzymes (ArMs) from scaffold proteins containing a p‐azido‐L‐phenylalanine (Az) residue and catalytically active bicyclononyne‐linked cofactors. This method showed broad scope with respect to both the scaffold and cofactor components, and...
Published in Tetrahedron Asymmetry