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Jared Lewis
Faculty Member, University of Chicago
Institution:
CCHF
Summary
Published articles Show More
Engineering a dirhodium artificial metalloenzyme for selective olefin cyclopropanation
Published in Nature Communications
Artificial metalloenzymes (ArMs) formed by incorporating synthetic metal catalysts into protein scaffolds have the potential to impart to chemical reactions selectivity that would be difficult to achieve using metal catalysts alone. In this work, we covalently link an alkyne-substituted dirhodium catalyst to a prolyl oligopeptidase containing a gen...
A General Method for Artificial Metalloenzyme Formation through Strain-Promoted Azide–Alkyne Cycloaddition
Published in Chem-Bio Informatics Journal
As good as the real thing: Strain‐promoted azide–alkyne cycloaddition can be used to generate artificial metalloenzymes (ArMs) from scaffold proteins containing a p‐azido‐L‐phenylalanine (Az) residue and catalytically active bicyclononyne‐linked cofactors. This method showed broad scope with respect to both the scaffold and cofactor components, and...
Manganese terpyridine artificial metalloenzymes for benzylic oxygenation and olefin epoxidation
Published in Tetrahedron Asymmetry
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