Jacqueline Lehmann-Che
Co-Responsable de l'équipe, Translational cancer studies
Institution:
USPC - SET - SVS
Summary
Published articles Show More
IDH-Mutation Is a Weak Predictor of Long-Term Survival in Glioblastoma Patients
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Published in PLoS ONE
BACKGROUND: A very small proportion of patients diagnosed with glioblastoma (GBM) survive more than 3 years. Isocitrate dehydrogenase 1 or 2 (IDH1/2) mutations define a small subgroup of GBM patients with favourable prognosis. However, it remains controversial whether long-term survivors (LTS) are found among those IDH1/2 mutated patients. METHODS:...
Functional TP53 mutations have no impact on response to cytotoxic agents in metastatic colon cancer.
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Published in Bulletin du Cancer
Background Survival of metastatic colon cancer (mCC) patients has considerably improved with optimization of new drugs regimen. Inactivation of TP53 pathway by TP53 mutations is observed in nearly half of colorectal tumors. The impact of such mutations has been poorly studied in the metastatic setting. Methods The files of 254 mCC treated in a...
HDAC inhibition does not induce estrogen receptor in human triple-negative breast cancer cell lines and patient-derived ...
...Published in Breast Cancer Research and Treatment
Several publications have suggested that histone deacetylase inhibitors (HDACis) could reverse the repression of estrogen receptor alpha (ERα) in triple-negative breast cancer (TNBC) cell lines, leading to the induction of a functional protein. Using different HDACis, vorinostat, panobinostat, and abexinostat, we therefore investigated this hypothe...
Theses Show More
Etudes des étapes précoces de l'infection des virus foamy
Dans le cycle réplicatif des rétrovirus, les étapes tardives de l'infection ont été élucidées ces dernières années alors que les étapes précoces, allant de l'entrée du virus jusqu'à l'intégration du génome dans celui de la cellule hôte, restent encore peu connues. Par le présent travail, nous avons tenté de répondre à un certain nombre de questions...
Nouvelle stratégie de transfert de gène (développement d'un vecteur spumaviral minimal dérivé du primate foamy virus typ...
FR
Experience
Co-Responsable de l'équipe
Université Paris Diderot
Translational cancer studies; U944/UMR7212, Pathologie et Virologie Moléculaire; Institut Universitaire d'Hématologie (IUH)
