I am a Staff Scientist in the Hunter lab. I am originally from Urumqi, China, went to college in Beijing, and got my Ph.D. from Indiana University School of Medicine. I study how ubiquitylation and sumoylation regulate cellular life, with a current focus on the structure and function of SUMO-binding proteins. Outside the lab, I love traveling with my family.
Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins.
Published in The EMBO Journal
The function of small ubiquitin-like modifier (SUMO)-binding proteins is key to understanding how SUMOylation regulates cellular processes. We identified two related Schizosaccharomyces pombe proteins, Rfp1 and Rfp2, each having an N-terminal SUMO-interacting motif (SIM) and a C-terminal RING-finger domain. Genetic analysis shows that Rfp1 and Rfp2...