N-Heterocyclic Carbene–Polyethylenimine Platinum Complexes with Potent in Vitro and in Vivo Antitumor Efficacy...
Published in Bioconjugate Chemistry
Selective Formation of cis-N-Heterocyclic Carbene-PtII-Pnictogen Complexes and in vitro Evaluation of Their Cytotoxic Ac...
Published in Chemische Berichte
Tridentate Complexes of Palladium(II) and Platinum(II) Bearing bis-Aryloxide Triazole Ligands: A Joint Experimental and ...
Published in Chemistry - An Asian Journal
Chemist Since 2015
Laboratoire national de Santé (Dudelange LU)
PhD Chemistry 2011 - 2014
Université de Strasbourg (Strasbourg FR)
Metal N-Heterocyclic Carbene (NHC) complexes are of great potential for cancer therapy. In particular, in vitro studies confirmed their significantly higher cytotoxicity than cisplatin. In this work, we introduced molecular diversity on new NHC-Pt complexes by coordination of various NHC precursors to platinum. As a second strategy, post-synthetic functionalization of Pt complexes has been fully investigated by: a) oxime formation, e.g. with a PSMA targeting urea derivative, b) ligand exchange reaction with hydrosoluble polyamines (PEI) and pnictogen-based ligands (phosphines, arsines, stibines), c) halogen exchange with iodide isotopesCytotoxic properties of these new compounds were evaluated in vitro. Best candidate was selected for in vivo evaluation on mice model showing for PEI-Pt similar tumour inhibition as oxaliplatin. Besides, no “visual” side effects were detected in contrast to oxaliplatin (hematomas). These outstanding results opened up new perspectives in the field of platinum-based drugs