Gary Braun
Post Doc Associate
Institution:
Ruoslahti Lab
Santa Barbara, CA, United States
https://www.mysciencework.com/profile/gary.braun
Summary
Published articles Show More
Transtumoral targeting enabled by a novel neuropilin-binding peptide
Published in Oncogene
We have recently described a class of peptides that improve drug delivery by increasing penetration of drugs into solid tumors. These peptides contain a C-terminal C-end Rule (CendR) sequence motif (R/K)XX(R/K), which is responsible for cell internalization and tissue-penetration activity. Tumor-specific CendR peptides contain both a tumor-homing m...
Neuropilin-1 and heparan sulfate proteoglycans cooperate in cellular uptake of nanoparticles functionalized by cationic ...
Published in Science Advances
Cell-penetrating peptides (CPPs) have been widely used to deliver nanomaterials and other types of macromolecules into mammalian cells for therapeutic and diagnostic use. Cationic CPPs that bind to heparan sulfate (HS) proteoglycans on the cell surface induce potent endocytosis; however, the role of other surface receptors in this process is unclea...
A free cysteine prolongs the half-life of a homing peptide and improves its tumor-penetrating activity.
Published in Journal of Controlled Release
The accessibility of extravascular tumor tissue to drugs is critical for therapeutic efficacy. We previously described a tumor-targeting peptide (iRGD) that elicits active transport of drugs and macromolecules (covalently coupled or co-administered) across the vascular wall into tumor tissue. Short peptides (iRGD is a 9-amino acid cyclic peptide) g...
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