Gail Sckisel
Postdoc
Institution:
Murphy Lab, dermatology-ucdavis
Davis, CA, United States
https://www.mysciencework.com/profile/gail.sckisel
Summary
Published articles Show More
Immunoediting and antigen loss: overcoming the achilles heel of immunotherapy with antigen non-specific therapies.
Published in Frontiers in Oncology
Cancer immunotherapy has emerged as a mainstream therapy option in the battle against cancer. Pre-clinical data demonstrates the ability of immunotherapy to harness the immune system to fight disseminated malignancy. Clinical translation has failed to recapitulate the promising results of pre-clinical studies although there have been some successes...
NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype.
...Published in The Journal of Immunology
Increasing evidence supports the hypothesis that cancer stem cells (CSCs) are resistant to antiproliferative therapies, able to repopulate tumor bulk, and seed metastasis. NK cells are able to target stem cells as shown by their ability to reject allogeneic hematopoietic stem cells but not solid tissue grafts. Using multiple preclinical models, inc...
Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immun...
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Published in Blood
Memory T cells exhibit tremendous antigen specificity within the immune system and accumulate with age. Our studies reveal an antigen-independent expansion of memory, but not naive, CD8(+) T cells after several immunotherapeutic regimens for cancer resulting in a distinctive phenotype. Signaling through T-cell receptors (TCRs) or CD3 in both mouse ...
