Frédéric Bouillaud

HK2 Recruitment to Phospho-BAD Prevents Its Degradation, Promoting Warburg Glycolysis by Theileria-Transformed Leukocyte...

Published in ACS Infectious Diseases

Theileria annulata infects bovine leukocytes, transforming them into invasive, cancer-like cells that cause the widespread disease called tropical theileriosis. We report that in Theileria-transformed leukocytes hexokinase-2 (HK2) binds to B cell lymphoma-2-associated death promoter (BAD) only when serine (S) 155 in BAD is phosphorylated. We show t...

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders

Published in Cell Stem Cell

Mitochondrial DNA (mtDNA) mutations frequently cause neurological diseases. Modeling of these defects has been difficult because of the challenges associated with engineering mtDNA. We show here that neural progenitor cells (NPCs) derived from human induced pluripotent stem cells (iPSCs) retain the parental mtDNA profile and exhibit a metabolic swi...

Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus

Published in Free Radical Biology and Medicine

Microglia fulfill important immunological functions in the brain by responding to pathological stresses and modulating their activities according to pro- or anti-inflammatory stimuli. Recent evidence indicates that changes in metabolism accompany the switch in microglia activation state, favoring glycolysis over oxidative phosphorylation when cells...

The Mitochondrial Uncoupling Protein: Structural and Genetic Studies

Published in Pediatric and Developmental Pathology

Chapter 18 The uncoupling proteins family: From thermogenesis to the regulation of ROS

Published in Acta Haematologica

The mitochondrial uncoupling protein UCP / genetic and structural studies

Published in Journal of Integrative Cardiology

Contrôle de la traduction d' UCP2 (mise en évidence d' une régulation par la glutamine)

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KMCP1, un nouveau transporteur mitochondrial rénal induit par le stress oxydatif et lors de la régénération tubulaire

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Etude du transport des UCPs (utilisation du modèle cellulaire CHO et de la reconstitution en protéoliposomes)

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