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Published in ACS Infectious Diseases
Theileria annulata infects bovine leukocytes, transforming them into invasive, cancer-like cells that cause the widespread disease called tropical theileriosis. We report that in Theileria-transformed leukocytes hexokinase-2 (HK2) binds to B cell lymphoma-2-associated death promoter (BAD) only when serine (S) 155 in BAD is phosphorylated. We show t...
Published in Cell Stem Cell
Mitochondrial DNA (mtDNA) mutations frequently cause neurological diseases. Modeling of these defects has been difficult because of the challenges associated with engineering mtDNA. We show here that neural progenitor cells (NPCs) derived from human induced pluripotent stem cells (iPSCs) retain the parental mtDNA profile and exhibit a metabolic swi...
Published in Free Radical Biology and Medicine
Microglia fulfill important immunological functions in the brain by responding to pathological stresses and modulating their activities according to pro- or anti-inflammatory stimuli. Recent evidence indicates that changes in metabolism accompany the switch in microglia activation state, favoring glycolysis over oxidative phosphorylation when cells...
Published in Pediatric and Developmental Pathology
Published in Acta Haematologica
Published in Journal of Integrative Cardiology
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Mitochondries, bioénergétique, métabolisme et signalisation; Département Endocrinologie, Métabolisme, Diabète (EMD); UMR 8104 / UMR_S1016, Institut Cochin; Faculté de Médecine
Cloning of the cDNA for the uncoupling protein UCP1