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Franck Morceau
Research Scientist, Project Leader
Institution:
LBMCC
Luxembourg, Luxembourg
https://www.mysciencework.com/profile/franck.morceau
Summary
Published articles Show More
Dual Induction of Mitochondrial Apoptosis and Senescence in Chronic Myelogenous Leukemia by Myrtucommulone A
Published in Anti-Cancer Agents in Medicinal Chemistry in Jan 11, 2015
Despite recent advances in the treatment of chronic myelogenous leukemia (CML), the development of drug resistance and minimal residual disease remain major challenges for the treatment of CML patients, thus highlighting the need to develop innovative new approaches to improve therapeutic outcome. Myrtucommulone A (MCA) is a nonprenylated acylphlor...
Long and Short Non-Coding RNAs as Regulators of Hematopoietic Differentiation
Published in International Journal of Molecular Sciences in Jul 10, 2013
Genomic analyses estimated that the proportion of the genome encoding proteins corresponds to approximately 1.5%, while at least 66% are transcribed, suggesting that many non-coding DNA-regions generate non-coding RNAs (ncRNAs). The relevance of these ncRNAs in biological, physiological as well as in pathological processes increased over the last t...
Evidence for distinct regulation processes in the aclacinomycin- and doxorubicin-mediated differentiation of human eryth...
Published in Biochemical pharmacology in Mar 11, 1996
Human erythroleukemic K 562 cells were induced to were induced to differentiate along the erythroid lineage by anthracycline antitumor drugs, such as aclacinomycin (ACLA) and doxorubicin (DOX). Subsequent stimulation of heme and globin synthesis led to a differential quantitative expression of hemoglobins. Gower 1 (epsilon2, zeta2) was the major ty...
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