Francis Lin

E-cadherin plays an essential role in collective directional migration of large epithelial sheets.

Published in Cellular and Molecular Life Sciences

In wound healing and development, large epithelial sheets migrate collectively, in defined directions, and maintain tight cell-cell adhesion. This type of movement ensures an essential function of epithelia, a barrier, which is lost when cells lose connection and move in isolation. Unless wounded, epithelial sheets in cultures normally do not have ...