Florence Noble

Netrin G1: its downregulation in the nucleus accumbens of cocaine-conditioned mice and genetic association in human coca...

Published in Addiction Biology

Netrin G1 is a presynaptic ligand involved in axonal projection. Although molecular mechanisms underlying cocaine addiction are still poorly understood, Netrin G1 might have a role as a regulator of anxiety, fear and spatial memory, behavioural traits impaired in the context of cocaine exposure. In this study, the Netrin G1 (Ntng1) expression was i...

What brings neurobiology to addictions?

Published in La Presse Médicale

Addictions are multifactorial, and there are no experimental models replicating all aspects of this pathology. The development of animal models reproducing the clinical symptoms of addictions allows significant advances in the knowledge of the neurobiological processes involved in addiction. Preclinical data highlight different neuroadaptatio...

Chapitre 6. Connaissances actuelles sur la neurobiologie du cannabis

Published in Cannabis

Originaire de l’Asie centrale, le cannabis est une plante dont les effets psychotropes sont connus depuis longtemps (cette plante est connue en Chine depuis plus de 6000 ans). Elle a longtemps été utilisée en médecine dans de nombreux pays comme aux États-Unis d’Amérique et en Europe de l’ouest et ce n’est qu’en 1942 qu’elle est retirée de la pharm...

[17] Inhibitors of neprilysin: Design, pharmacological and clinical applications

Published in The Journal of antimicrobial chemotherapy