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Flavia Radogna
PhD
Institution:
LBMCC
Luxembourg
https://www.mysciencework.com/profile/flavia.radogna
Summary
Published articles Show More
Cell type-dependent ROS and mitophagy response leads to apoptosis or necroptosis in neuroblastoma
Published in Oncogene
A limiting factor in the therapeutic outcome of children with high-risk neuroblastoma is the intrinsic and acquired resistance to common chemotherapeutic treatments. Here we investigated the molecular mechanisms by which the hemisynthetic cardiac glycoside UNBS1450 overcomes this limitation and induces differential cell death modalities in both neu...
Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic ...
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Published in Leukemia
Leukemia accepted article preview online, 22 November 2016. doi:10.1038/leu.2016.341
Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal c...
...Published in Cancer Letters
Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binde...
