Farzad Pakdel

Co-Responsable du groupe, Transcription, Environment and Cancer

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https://www.mysciencework.com/profile/farzad.pakdel

Summary

Published articles Show More

Several synthetic progestins disrupt the glial cell specific-brain aromatase expression in developing zebra fish

Cano-Nicolau, Joel Garoche, Clementine Hinfray, Nathalie Pellegrini, Elisabeth Boujrad, Noureddine Farzad Pakdel Kah, Olivier Brion, François

The effects of some progestins on fish reproduction have been recently reported revealing the hazard of this class of steroidal pharmaceuticals. However, their effects at the central nervous system level have been poorly studied until now. Notwithstanding, progesterone, although still widely considered primarily a sex hormone, is an important agent...

The actin/MKL1 signalling pathway influences cell growth and gene expression through large-scale chromatin reorganizatio...

Flouriot, Gilles Huet, Guillaume Demay, Florence Farzad Pakdel Boujrad, Noureddine Michel, Denis

Published in Journal of Parallel and Distributed Computing

In addition to soluble factors, mechanical constraints and extracellular matrix stiffness are important regulators of cell fate that are mediated by cytoskeletal modifications. The EMT (epithelial-mesenchymal transition) that occurs during normal development and malignant progression is a typical example of the phenotypic switch associated with pro...

COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration.

Boudot, Antoine Kerdivel, Gwenneg Lecomte, Sylvain Flouriot, Gilles Desille, Mireille Godey, Florence Leveque, Jean Tas, Patrick Le Dréan, Yves Farzad Pakdel ...

Published in Human Molecular Genetics

Together, our mechanistic in vitro assays and in vivo results suggest that a reduction in chemokine CXCL12 expression, with an enhancement of CXCR4 expression, provoked by COUP-TFI, could be associated with an increase in the invasive potential of breast cancer cells.