Fabien Guidez
Responsable de l'équipe, Cellules souches et voies de signalisation
Institution:
USPC - SET - SVS
Summary
Published articles Show More
GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated p...
...Published in Journal of Hematology & Oncology
BACKGROUND:In spite of the recent discovery of genetic mutations in most myelodysplasic (MDS) patients, the pathophysiology of these disorders still remains poorly understood, and only few in vivo models are available to help unravel the disease.METHODS:We performed global specific gene expression profiling and functional pathway analysis in purifi...
Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network
...Published in Nature Genetics
Juvenile myelomonocytic leukemia (JMML) is a rare and severe myelodysplastic and myeloproliferative neoplasm of early childhood initiated by germline or somatic RAS-activating mutations. Genetic profiling and whole-exome sequencing of a large JMML cohort (118 and 30 cases, respectively) uncovered additional genetic abnormalities in 56 cases (47%). ...
Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases.
Published in Epigenetics & Chromatin
Consequently, SIRT1 and HDAC3 mediated-PLZF deacetylation provides for rapid control and fine-tuning of PLZF activity through post-transcriptional modification to regulate gene expression and cellular homeostasis.
Experience
Responsable de l'équipe
Université Paris Diderot
Cellules souches et voies de signalisation; UMR1131, Hémopathies myeloides : cellules souches, modèles précliniques et recherche translationelle; Institut Universitaire d'Hématologie (IUH)
