PhD
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Summary
Published articles Show More
Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal c...
...Published in Cancer Letters
Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binde...
Garlic-derived natural polysulfanes as hydrogen sulfide donors: Friend or foe?
Published in Food and Chemical Toxicology
In vitro and in vivo studies reported the anti-cancer potential of organosulfur compounds (OSCs) as they trigger biological effects leading to cell cycle arrest with accumulation of cells in G2/M, alteration of the microtubular network, modulation of Bcl-2 family protein expression patterns and changes of the redox status. Despite these well-descri...
Experience
PhD Candidate October 2014 - December 2017
Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC) (Luxembourg LU)
PhD thesis: Analysis of the role of garlic-derived polysulfanes on the microtubular network and autophagy: anticancer effect in colorectal cancer
Education
Master Degree September 2011 - September 2013
Univesité de Strasbourg (Strasbourg FR)
Master thesis: development of the immune cell chamber of a microfluidics-based gastrointestinal tract co-culture device
