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Erik Sorensen
Faculty Member, Princeton University
Institution:
CCHF
Summary
Published articles Show More
An expedient synthesis of maraviroc (UK-427,857) via C–H functionalization
Published in Tetrahedron Letters
A new, concise synthesis of the CCR-5 receptor antagonist maraviroc (UK-427,857) from 3-phenyl-1-propanol has been completed in four steps featuring a site-selective C–H functionalization.
An Enantiospecific Synthesis of Jiadifenolide
Published in Angewandte Chemie International Edition in English
A Robinson annulation, van Leusen homologation, and a desymmetrizing C-H oxidation enabled an enantiospecific synthesis of the neurotrophic natural product jiadifenolide. From a pulegone-derived building block, a key propellane intermediate was constructed through the use of simple reagents in a highly diastereoselective fashion. A short series of ...
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