Dr. Maverakis runs a UC Davis clinic that specializes in the treatment of patients with severe immune-mediated diseases involving the skin. He is also an immunology researcher who holds early career awards from the Howard Hughes Medical Institute and the Burroughs Wellcome Fund.
Dr. Maverakis became interested in immunology as an undergraduate at the University of California-Los Angeles where he earned departmental honors for his work on a mouse model of multiple sclerosis, experimental autoimmune encephalomyelitis. He then continued his research endeavors at Harvard Medical School (HMS) in Boston where he graduated summa cum laude in 2003. He is in a elite group of only 15 students in over 220 years to have graduated with highest honors from HMS. After completing an internship in internal medicine at Harvard’s Beth Israel Deaconess Medical Center, Dr. Maverakis came to UC Davis to complete a residency in dermatology and in 2007 he joined the faculty. He holds appointments in the Department of Dermatology and in the Department of Medical Microbiology and Immunology. His group is focused on characterizing autoreactive T cell repertoires in humans with immune mediated skin diseases. Such work might lead to better targeted therapies for these types of diseases.
Another focus of the Maverakis lab is to study malignancies that are able induce an immune response. His lab is looking at ways to boost the immune response to the tumor.
His group has published in a variety of journals including the Journal of Clinical Investigation, Proceedings of the National Academy of Sciences, the Journal of Experimental Medicine and Nature Reviews Immunology.
Emanual Maverakis
Associate Professor
Summary
Published articles Show More
Acrodermatitis enteropathica.
Published in Dermatology online journal
A 13-year-old girl presented with a history of red scaly plaques involving the chest, arms and legs beginning in infancy. Punch biopsy revealed psoriasiform hyperplasia and pallor of the epidermis. The patient s serum zinc level was 36 mug/dl [nl. 66-144 mug/dl]. A diagnosis of acrodermatitis enteropathica was established and the patient responded ...
A T cell-binding fragment of fibrinogen can prevent autoimmunity.
...Published in Journal of Autoimmunity
The C-terminal domain of the fibrinogen gamma chain (gammaC) has been shown to bind to the integrins alphaIIbbeta3, alphaMbeta2 and alphaVbeta3. It has also been reported that a peptide derived from the alphaMbeta2-binding site of gammaC can suppress an animal model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). Here we hav...
Tuning microenvironment modulus and biochemical composition promotes human mesenchymal stem cell tenogenic differentiati...
Published in Journal of Biomedical Materials Research Part A
Mesenchymal stem cells (MSCs) are promising for the regeneration of tendon and ligament tissues. Toward realizing this potential, microenvironment conditions are needed for promoting robust lineage-specific differentiation into tenocytes/ligament fibroblasts. Here, we utilized a statistical design of experiments approach to examine combinations of ...
