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Bee venom processes human skin lipids for presentation by CD1a
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Published in Journal of Experimental Medicine
Venoms frequently co-opt host immune responses, so study of their mode of action can provide insight into novel inflammatory pathways. Using bee and wasp venom responses as a model system, we investigated whether venoms contain CD1-presented antigens. Here, we show that venoms activate human T cells via CD1a proteins. Whereas CD1 proteins typically...
Cutting Edge: IVIg inhibits iNKT cell-mediated allergic airway inflammation through FcRIIIAdependent mechanisms
...Published in The Journal of Immunology
Despite their increasing use in autoimmune, inflammatory, and allergic conditions, the mechanism of action of i.v. Igs (IVIg) is poorly understood. On the basis of the critical role of invariant NKT (iNKT) cells in allergic airway inflammation (AAI) and their constitutive expression of the low-affinity IgG receptor FcgRIIIA, we surmised that IVIg t...
A natural protective function of invariant NKT cells in a mouse model of innate-cell-driven lung inflammation.
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Published in European Journal of Immunology
Activation of invariant natural killer T (iNKT) cells by treatment with their α-galactosyl ceramide ligand provides therapeutic benefits in several immune inflammatory settings. Given the artificial nature of this stimulation, the natural regulatory functions of iNKT remain uncertain. Addressing this issue in a mouse model of innate-cell-driven lun...
