Doug Kellogg

Concurrent dermatomyositis and metastatic breast carcinoma: case report.

Published in Henry Ford Hospital medical journal

Cdk1 coordinates cell-surface growth with the cell cycle.

Published in Nature Cell Biology

The mechanisms that control cell growth during the cell cycle are poorly understood. In budding yeast, cyclin dependent kinase 1 (Cdk1) triggers polarization of the actin cytoskeleton and bud emergence in late G1 through activation of the Cdc42 GTPase. However, Cdk1 is not thought to be required for subsequent growth of the bud. Here, we show that ...

Compact modeling of allosteric multisite proteins: application to a cell size checkpoint.

Published in PLoS Computational Biology

We explore a framework to model the dose response of allosteric multisite phosphorylation proteins using a single auxiliary variable. This reduction can closely replicate the steady state behavior of detailed multisite systems such as the Monod-Wyman-Changeux allosteric model or rule-based models. Optimal ultrasensitivity is obtained when the activ...