Dinesh S. Rao received a B.S. summa cum laude in Biochemistry and an M.D. from Case Western Reserve University, Cleveland, USA. During this time he developed a deep interest in the pathogenesis of cancer, completing several projects in cancer research during medical school, and went on to a research fellowship at the University of Michigan. There, he made a seminal discovery implicating clathrin mediated trafficking of growth factor receptor tyrosine kinases in the pathogenesis of oncogenic transformation. He then combined clinical training in the pathology of hematologic diseases with further research training in the laboratory of Nobel laureate David Baltimore at Caltech. His research came to focus on the involvement of microRNAs in hematologic development, particularly B-cell development and immunity, and cancer, and resulted in several high-impact publications in well-regarded journals. His research interests include how microRNAs and other non-coding RNAs regulate hematopoietic development and cancer. He combines running a vibrant research laboratory with a busy diagnostic service in leukemia and lymphoma pathology.

Dinesh S. Rao
Assistant Professor, Pathology and Laboratory Medicine Hematopathology & Hematology
Summary
Published articles Show More
MicroRNA-146a modulates B-cell oncogenesis by targeting Egr1
Published in Oncotarget
miR-146a is a NF-κB induced microRNA that serves as a feedback regulator of this critical pathway. In mice, deficiency of miR-146a results in hematolymphoid cancer at advanced ages as a consequence of constitutive NF-κB activity. In this study, we queried whether the deficiency of miR-146a contributes to B-cell oncogenesis. Combining miR-146a defic...
BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia
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Published in Molecular Cancer
Background A new class of non-coding RNAs, known as long non-coding RNAs (lncRNAs), has been recently described. These lncRNAs are implicated to play pivotal roles in various molecular processes, including development and oncogenesis. Gene expression profiling of human B-ALL samples showed differential lncRNA expression in samples with particular ...
Long non-coding RNA in hematologic malignancies
Published in Briefings in Functional Genomics and Proteomics