Dr. O’Shea earned her bachelor’s degree in Biochemistry from University College Cork, Ireland. She did her doctorate in Immunology at the I.C.R.F. and Imperial College London, revealing key signals that regulate the development of our immune systems. After her graduate studies, she was selected for a Raleigh International expedition to Namibia where she worked on environmental, conservation and development projects. She did her postdoctoral research in Dr. Frank McCormick’s lab at UCSF on the prototype for oncolytic viral cancer therapy, ONYX-015. She has received numerous awards for her research. In her spare time, she is an avid outdoors enthusiast who loves to climb and explore the world’s most adventurous and exotic destinations.

Clodagh O'Shea
Associate Professor
Summary
Published articles Show More
Metabolism goes viral.
Published in Cell Metabolism
Viral and cellular oncogenes converge in targeting critical protein interaction networks to reprogram the cellular DNA and protein replication machinery for pathological replication. In this issue, Thai et al. (2014) show that adenovirus E4ORF1 activates MYC glycolytic targets to induce a Warburg-like effect that converts glucose into nucleotides f...
Adenovirus overrides cellular checkpoints for protein translation.
Published in Cell Cycle
mTOR is a critical regulator of protein translation, and plays an important role in controlling cellular replication. Recent studies indicate that nutrient and growth factor mediated activation of mTOR is deregulated in human cancer, and therefore represents an attractive tumor target. However, activation of mTOR is a complex process that is not ye...
Modulation of the ARF-p53 pathway by the small DNA tumor viruses.
Published in Cell Cycle
The small DNA tumor viruses encode proteins that subvert many of the pivotal growth regulatory pathways within the cell to facilitate their own replication. The cell responds to viral infection/proteins by activating the p53 tumor suppressor pathway. Activation of p53 could impair a productive viral infection at many levels, including the inhibitio...