Group Leader of Cell Death Team
Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal c......
Published in Cancer Letters in Dec 06, 2017
Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binde...
Published in Biochemical Pharmacology in Feb 24, 2017
Cardiac glycosides (CGs) are approved for the treatment of cardiovascular alterations and their known cellular target is the alpha subunit of the sodium (Na+)/potassium (K+)-ATPase (NKA). Pharmacologically, they represent a well-known generation of drugs for treating cardiovascular problems, thus allowing the investigation of potential dose-depende...
Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic ......
Published in Leukemia in Nov 22, 2016
Leukemia accepted article preview online, 22 November 2016. doi:10.1038/leu.2016.341
Published in Accounting Auditing & Accountability Journal in Feb 12, 2016
Cancer and aging are two similar processes representing the final outcome of time-dependent accumulation of various irreversible dysfunctions, mainly caused by stress-induced DNA and cellular damages. Apoptosis and senescence are two types of cellular response to damage that are altered in both cancer and aging, albeit through different mechanisms....
Researcher_ Cell Death Team Leader Since January 2011
Molecular characterization of the cell death pathways triggered by compounds of natural origin. Identification and targeting of pro-survival pathways in cancer cells. Analysis of the role of the pro-inflammatory mediator cyclooxigenase-2 (COX-2) in cancer. Identification of novel compounds targeting inflammation for chemopreventive and chemotherapeutic purposes.
Post-Doc January 2007 - December 2011
Role of the pro-inflammatory mediator cyclooxigenase-2 in chemoresistance and tumor promotion. Elucidation of the cell death mechanisms induced by compounds of natural origin in cancer cells.
Research Fellow December 2004 - December 2006
PTV_University of Rome Tor Vergata (Rome IT)
Analysis of the biological effects of magnetic fields. Analysis of the mechanisms of action of novel anti-cancer compounds.
PhD student November 2001 - November 2004
Role of calcium alterations in apoptotic and survival pathways in cancer cell models.
Ph.D. in Cellular and Molecular Biology January 2005 - January 2005
Calcium alterations in apoptotic and survival pathways