Group Leader of Cell Death Team
Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal c......
Published in Cancer Letters
Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binde...
Published in Biochemical Pharmacology
Cardiac glycosides (CGs) are approved for the treatment of cardiovascular alterations and their known cellular target is the alpha subunit of the sodium (Na+)/potassium (K+)-ATPase (NKA). Pharmacologically, they represent a well-known generation of drugs for treating cardiovascular problems, thus allowing the investigation of potential dose-depende...
Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic ......
Published in Leukemia
Leukemia accepted article preview online, 22 November 2016. doi:10.1038/leu.2016.341
Published in Current Topics in Medicinal Chemistry
Cancer and aging are two similar processes representing the final outcome of time-dependent accumulation of various irreversible dysfunctions, mainly caused by stress-induced DNA and cellular damages. Apoptosis and senescence are two types of cellular response to damage that are altered in both cancer and aging, albeit through different mechanisms....
Researcher_ Cell Death Team Leader Since January 2012
Molecular characterization of the cell death pathways triggered by compounds of natural origin. Identification and targeting of pro-survival pathways in cancer cells. Analysis of the role of the pro-inflammatory mediator cyclooxigenase-2 (COX-2) in cancer. Identification of novel compounds targeting inflammation for chemopreventive and chemotherapeutic purposes.
Post-Doc January 2007 - December 2011
Role of the pro-inflammatory mediator cyclooxigenase-2 in chemoresistance and tumor promotion. Elucidation of the cell death mechanisms induced by compounds of natural origin in cancer cells.
Research Fellow December 2004 - December 2006
PTV_University of Rome Tor Vergata (Rome IT)
Analysis of the biological effects of magnetic fields. Analysis of the mechanisms of action of novel anti-cancer compounds.
PhD student November 2001 - November 2004
Role of calcium alterations in apoptotic and survival pathways in cancer cell models.
Ph.D. in Cellular and Molecular Biology November 2001 - October 2004
Calcium alterations in apoptotic and survival pathways
Italian National Scientific Qualification as Full Professor in Applied Biology (05/F1) July 2017
Italian National Scientific Qualification as Full Professor in Applied Biology (05/F1) - Italian Ministry of Education, University and Research
Italian National Scientific Qualification as Associate Professor in Applied Biology (05/F1) April 2017
Italian National Scientific Qualification as Associate Professor in Applied Biology (05/F1) - Italian Ministry of Education, University and Research
Outstanding Paper Award January 2017
Outstanding Paper Award (College of Pharmacy, Seoul National University, Seoul, South Korea)
Italian National Qualification to the Public Practice of the Profession of Biologist September 2001
Italian National Qualification to the Public Practice of the Profession of Biologist (University of Rome Tor Vergata, Rome Italy)