Group Leader of Cell Death Team
Published in Cell Death and Disease in Jun 07, 2015
Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-cancer activities. Despite their well-established target, the sodium/potassium (Na + /K +)-ATPase, downstream mechanisms remain poorly elucidated. UNBS1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin extracted from the plant Calotropis ...
Chemical Properties and Mechanisms Determining the Anti-Cancer Action of Garlic-Derived Organic Sulfur Compounds
Published in Anti-Cancer Agents in Medicinal Chemistry
Organic sulfur compounds (OSCs) derived from plants, fungi or bacteria can serve as chemopreventive and/or chemotherapeutic agents and have been attracting medical and research interest as a promising source for novel anti-cancer agents. Garlic, which has long been used as a medicinal plant in different cultures due to its multiple beneficial effec...
Subapoptogenic Oxidative Stress Strongly Increases the Activity of the Glycolytic Key Enzyme Glyceraldehyde 3-Phosphate ...
Published in Annals of the New York Academy of Sciences
We have previously shown that oxidative stress induced by an apoptogenic dose of H2O2 leads to a temporary block of glycolytic flux via inactivation of the glycolytic key enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in U937 cells. This corresponds to the activation of a cell defense pathway that is triggered to repair stress-induced dama...
Published in Current Drug Targets in February 2016
Cancer and aging are two similar processes representing the final outcome of time-dependent accumulation of various irreversible dysfunctions, mainly caused by stress-induced DNA and cellular damages. Apoptosis and senescence are two types of cellular response to damage that are altered in both cancer and aging, albeit through different mechanisms....
Researcher_ Cell Death Team Leader Since January 2011
Molecular characterization of the cell death pathways triggered by compounds of natural origin. Identification and targeting of pro-survival pathways in cancer cells. Analysis of the role of the pro-inflammatory mediator cyclooxigenase-2 (COX-2) in cancer. Identification of novel compounds targeting inflammation for chemopreventive and chemotherapeutic purposes.
Post-Doc January 2007 - December 2011
Role of the pro-inflammatory mediator cyclooxigenase-2 in chemoresistance and tumor promotion. Elucidation of the cell death mechanisms induced by compounds of natural origin in cancer cells.
Research Fellow December 2004 - December 2006
PTV_University of Rome Tor Vergata (Rome IT)
Analysis of the biological effects of magnetic fields. Analysis of the mechanisms of action of novel anti-cancer compounds.
PhD student November 2001 - November 2004
Role of calcium alterations in apoptotic and survival pathways in cancer cell models.
Ph.D. in Cellular and Molecular Biology January 2005 - January 2005
Calcium alterations in apoptotic and survival pathways