Epigenetics team
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Published articles Show More
Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent induci...
...Published in Oncotarget
We characterized the brominated alkaloid Isofistularin-3 (Iso-3), from the marine sponge Aplysina aerophoba, as a new DNA methyltransferase (DNMT)1 inhibitor. Docking analysis confirmed our in vitro DNMT inhibition data and revealed binding of Iso-3 within the DNA binding site of DNMT1. Subsequent increased expression of tumor suppressor gene aryl ...
Editorial (Thematic Issue: Novel Pharmaceutical Approaches by Natural Compound-Derived Epigenetic Regulators: Epigenetic...
Published in Current Topics in Medicinal Chemistry
Bispecific Antibodies: An Innovative Arsenal to Hunt, Grab and Destroy Cancer Cells
Published in Current Topics in Medicinal Chemistry
Targeted cellular immunotherapy with bifunctional antibodies (bsAbs) has emerged as a promising therapeutic approach for cancer over the last two decades. Progress in antibody engineering has led to the generation of many different types of antibody-derived entities that display at least two binding specificities. Most bsAbs consist of large IgG-li...
Preprints Show More
Roles of Apoptosis and Cellular Senescence in Cancer and Aging
Published in Current Topics in Medicinal Chemistry
Cancer and aging are two similar processes representing the final outcome of time-dependent accumulation of various irreversible dysfunctions, mainly caused by stress-induced DNA and cellular damages. Apoptosis and senescence are two types of cellular response to damage that are altered in both cancer and aging, albeit through different mechanisms....
