Published in Methods in Molecular Biology
Gene therapy is a promising approach for the treatment of a variety of disorders including genetic diseases and cancer. Among the viral vectors used in gene therapy, the lentiviral vector, based on HIV-1, is the only integrative vector able to transduce nondividing cells. The first generation of lentiviral vector was established in 1996. Since then...
Published in Human Gene Therapy
Duchenne muscular dystrophy (DMD) is an X-linked genetic disease characterized by the absence of dystrophin (427 kDa). An approach to eventually restore this protein in patients with DMD is to introduce into their muscles a plasmid encoding dystrophin cDNA. Because the phenotype of the dystrophic dog is closer to the human phenotype than is the mdx...
Published in Skeletal Muscle
postdoc Since September 2014
Stanford University (stanford US)
PhD September 2007 - December 2010
Université Laval (Quebec city CA)
Duchenne muscular dystrophy