The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B....
Published in Journal of Endodontics
Cdc48/p97 is an evolutionary conserved ubiquitin-dependent chaperone involved in a broad array of cellular functions due to its ability to associate with multiple cofactors. Aside from its role in removing RNA polymerase II from chromatin after DNA damage, little is known about how this AAA-ATPase is involved in the transcriptional process. Here, w...
Published in The Lancet Infectious Diseases
These results suggest that histone modifications impact splicing of distinct subsets of genes using distinct pathways.
Responsable de l'équipe Since 2014
Ubiquitin and dynamics or molecular scaffolds; U944/UMR7212, Pathologie et Virologie Moléculaire; Institut Universitaire d'Hématologie (IUH)