Bruno Villoutreix

Pharmacogenomics of the cytochrome P450 2C family: impacts of amino acid variations on drug metabolism

Published in Drug Discovery Today

Pharmacogenomics investigates DNA and RNA variations in the human genome related to drug responses. Cytochrome P450 (CYP) is a supergene family of drug-metabolizing enzymes responsible for the metabolism of approximately 90% of human drugs. Among the major CYP isoforms, the CYP2C subfamily is of clinical significance because it metabolizes approxim...

1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases

Published in Journal of the American Society of Nephrology

Identification by in silico and in vitro screenings of small organic molecules acting as reversible inhibitors of kallik...

Published in European Journal of Medicinal Chemistry