Current research projects: Find in silico tools (usually freely available) that help drug discovery.
Pharmacogenomics of the cytochrome P450 2C family: impacts of amino acid variations on drug metabolism
Published in Drug Discovery Today
Pharmacogenomics investigates DNA and RNA variations in the human genome related to drug responses. Cytochrome P450 (CYP) is a supergene family of drug-metabolizing enzymes responsible for the metabolism of approximately 90% of human drugs. Among the major CYP isoforms, the CYP2C subfamily is of clinical significance because it metabolizes approxim...
Published in Journal of the American Society of Nephrology
Identification by in silico and in vitro screenings of small organic molecules acting as reversible inhibitors of kallik...
Published in European Journal of Medicinal Chemistry
Directeur du laboratoire
Molécules Thérapeuthiques in Silico; UFR Sciences du Vivant